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Hormone Receptor Upregulation

Meaning

Hormone receptor upregulation is a specific physiological process where the number of hormone receptors expressed on the surface or within the interior of a target cell increases in response to a stimulus, typically a prolonged period of low hormone concentration. This mechanism is a crucial component of cellular communication, designed to enhance the cell’s sensitivity to a diminished hormonal signal. Clinically, it represents a potential therapeutic pathway to improve target tissue responsiveness without necessarily increasing the circulating hormone dose.