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Hormone Receptor Turnover

Meaning

Hormone Receptor Turnover describes the continuous, tightly regulated biological process of synthesizing, transporting, activating, internalizing, degrading, and recycling hormone receptors within a target cell. This dynamic process is a crucial homeostatic mechanism that allows cells to rapidly adjust their sensitivity to circulating hormone levels. The rate of receptor turnover is a key determinant of a tissue’s responsiveness to hormonal signals, playing a critical role in adaptation and preventing chronic overstimulation or desensitization. A disruption in this intricate balance can lead to states of hormonal resistance or hypersensitivity.