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Hormone Receptor Substrate

Meaning

A Hormone Receptor Substrate is a molecule, often a lipid or a lipid-derived entity, that directly interacts with a hormone receptor or a receptor-associated protein to modulate its activity or stability. This term acknowledges the structural and regulatory role of the cellular environment, particularly the lipid membrane, in dictating the effectiveness of hormonal signaling. For steroid hormones, the receptor substrate often refers to the specific lipid composition of the nuclear or plasma membrane that influences receptor trafficking and ligand binding affinity. It is a critical concept in understanding tissue-specific hormone sensitivity.