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Hormone Receptor Sensitivity

Meaning

Hormone Receptor Sensitivity refers to the degree of responsiveness of a cell’s hormone receptors to the presence of their corresponding hormonal ligand. This critical factor dictates the magnitude of the biological effect produced by a given concentration of hormone, acting independently of the circulating hormone level itself. Reduced sensitivity, often due to chronic overexposure or inflammation, is a common mechanism of endocrine dysfunction, such as the insulin resistance seen in metabolic syndrome.