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Hormone Receptor Crosstalk

Meaning

Hormone Receptor Crosstalk describes the complex, integrated communication and regulatory interaction occurring between distinct signaling pathways activated by different hormone receptors within a single cell. This phenomenon signifies that the activation state of one receptor, such as the androgen receptor, can directly or indirectly influence the activity, sensitivity, or expression of a separate receptor, like the glucocorticoid or estrogen receptor. Understanding this intricate dialogue is crucial for comprehending the holistic nature of the endocrine system and accurately predicting the net physiological effect of multi-hormone therapies.