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Hormone Ratio Optimization

Meaning

Hormone Ratio Optimization is the clinical strategy focused on achieving ideal proportional relationships between key synergistic or antagonistic hormones, rather than simply normalizing absolute individual hormone concentrations. The biological effect of a hormone is often dictated by its ratio to another, such as the estrogen-to-progesterone ratio or the testosterone-to-estradiol ratio, which profoundly affects receptor binding and signaling. This optimization is critical because imbalances in these ratios, even with ‘normal’ individual levels, can drive symptoms and pathology. The focus is on the systemic harmony required for true endocrine health and longevity.