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Hormone Optimization Plateau

Meaning

The Hormone Optimization Plateau describes a clinical state in which an individual undergoing hormone replacement or modulation therapy experiences a significant slowing or cessation of further symptomatic improvement, despite achieving laboratory values within the target physiological range. This plateau indicates that while the primary hormonal deficiency has been corrected, other underlying factors—such as receptor sensitivity, nutritional status, or chronic inflammation—are limiting further clinical progress. It necessitates a strategic shift from simple replacement to a broader, integrative approach.