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Hormone-Microbiome Interaction

Meaning

The Hormone-Microbiome Interaction describes the complex, reciprocal communication and metabolic influence between the host’s endocrine system and the vast community of microorganisms residing primarily in the gastrointestinal tract. Gut microbiota produce enzymes that metabolize and recycle hormones, such as estrogens and androgens, thereby influencing their circulating bioavailability and overall systemic effect. Conversely, host hormones can alter the composition and function of the gut microbiome, impacting gut barrier integrity and immune response. This emerging area of research is critical for understanding conditions ranging from obesity and metabolic syndrome to certain hormone-sensitive cancers.