Hormone Metabolite Tracking is the analytical process of identifying and quantifying the end-products created when parent hormones, such as estrogens or androgens, are broken down and prepared for excretion from the body via conjugation pathways. This provides a picture of hormone processing load.
Origin
This practice originates from advancements in mass spectrometry and analytical chemistry, allowing for detailed profiling of endocrine pathways beyond simply measuring the circulating parent compounds in serum. It is a product of analytical precision.
Mechanism
Tracking involves tracing the biochemical cascade from the active hormone through necessary modifications like hydroxylation, methylation, and glucuronidation; this reveals the specific metabolic routes being utilized, which is crucial for understanding individual endocrine clearance efficiency.
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