What is the Origin of Hormone Metabolite Screening?

The technique is an evolution of traditional endocrinology, driven by advances in mass spectrometry and chromatography. While initial hormone testing focused on circulating levels, the concept of metabolite screening gained prominence from toxicology and functional medicine, recognizing that the pathways of hormone breakdown are as important as their production.

What is the Mechanism of Hormone Metabolite Screening?

The screening quantifies specific metabolites, such as the various forms of estrogen metabolites (e.g., 2-OH, 4-OH, 16-OH) or androgen metabolites (e.g., androsterone, etiocholanolone). These profiles reveal the efficiency of phase I and phase II liver detoxification, indicating whether hormones are being metabolized down protective or potentially harmful pathways. This detailed mechanistic understanding guides precise nutritional and clinical interventions to optimize detoxification and balance.

Hormone Metabolite Screening ∞ Area

Hormone Metabolite Screening

Meaning

This advanced diagnostic procedure involves analyzing the breakdown products, or metabolites, of key hormones in biological fluids such as urine, saliva, or blood, rather than just the parent hormones themselves. This screening provides a detailed, dynamic view of how the body is processing and clearing hormones, offering critical insight into metabolic pathways that affect health and disease risk. It moves beyond simple concentration levels to assess the complete hormonal lifecycle.