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Hormone-Cognition Axis

Meaning

The Hormone-Cognition Axis refers to the intricate, bidirectional signaling network that connects the endocrine system’s circulating hormones with the brain’s cognitive centers, profoundly influencing processes like memory, attention, executive function, and mood. This axis recognizes that hormones such as estrogens, androgens, thyroid hormones, and cortisol are not just peripheral regulators but potent neuromodulators that directly affect neuronal structure and function. Maintaining the integrity and balance of this axis is paramount for preserving mental acuity and emotional well-being throughout the lifespan. Dysfunction within this critical system often manifests as significant cognitive complaints.