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Hormone Clearance Efficiency

Meaning

Hormone Clearance Efficiency is a measure of the body’s ability, primarily through hepatic (liver) and renal (kidney) metabolism, to rapidly and effectively inactivate and eliminate circulating hormones and their metabolites from the bloodstream. High efficiency ensures that hormonal signals are precise and transient, preventing chronic over-stimulation of target tissues and maintaining a healthy hormonal pulsatility. Poor clearance can lead to the accumulation of both active hormones and potentially toxic or estrogenic metabolites, disrupting endocrine homeostasis and increasing disease risk. This metric is crucial for understanding an individual’s unique hormonal milieu and managing personalized hormone replacement therapies.