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Hormone-Brain Axis

Meaning

The Hormone-Brain Axis refers to the intricate, bidirectional communication network that connects the endocrine system, which secretes hormones, with the central nervous system, which controls perception, thought, and behavior. This complex axis involves hormones from peripheral glands influencing brain function and, conversely, the brain regulating hormone release via the hypothalamus and pituitary gland. This constant interplay is fundamental to maintaining homeostasis, regulating mood, energy balance, stress response, and reproductive function. Dysregulation within this axis is implicated in numerous clinical conditions, including anxiety, depression, and metabolic disorders.