What is the Origin of Hormone Bioavailability Mapping?

This advanced diagnostic concept merges traditional endocrinology with modern analytical chemistry and clinical pharmacology, recognizing that serum concentration alone is an insufficient proxy for true biological activity. The "mapping" analogy emphasizes the systematic, multi-point assessment across the entire endocrine pathway.

What is the Mechanism of Hormone Bioavailability Mapping?

The process involves measuring total hormone, Sex Hormone Binding Globulin (SHBG), albumin, and calculating the free and bioavailable indices to determine the unbound fraction. Furthermore, measuring key hormone metabolites in urine or saliva can map the rates of phase I and phase II hepatic clearance, while clinical assessment and genetic testing may inform receptor sensitivity. This holistic data integration allows clinicians to visualize and correct inefficiencies at any point in the hormone's lifecycle.

Hormone Bioavailability Mapping ∞ Area

Hormone Bioavailability Mapping

Meaning

A comprehensive diagnostic process that extends beyond measuring total and free hormone levels to systematically assess the complete cascade of hormone action, from secretion to cellular receptor interaction and clearance. This mapping provides a granular view of the biologically active fraction of a hormone and its ultimate impact on target tissues. It is a crucial tool for precise hormonal therapy, revealing disconnects between serum levels and clinical effect.