The strategic clinical and physiological process of increasing the concentration of unbound, biologically active hormone molecules circulating in the bloodstream. This enhancement ensures maximal binding to target receptors and a robust physiological effect.
Origin
This term is central to clinical endocrinology and pharmacology, combining the concept of “hormone” (chemical messenger) with “bioavailability” (the fraction available for action). “Enhancement” denotes a therapeutic goal of optimizing the hormone’s impact.
Mechanism
Enhancement is often achieved by modulating the hepatic synthesis of carrier proteins, such as Sex Hormone-Binding Globulin (SHBG), which binds and inactivates steroid hormones. It can also involve optimizing the metabolic conversion of prohormones into their active forms. This optimization is a key strategy in hormonal health to ensure that existing or administered hormones exert their full intended effect on target tissues.
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