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Hormonal Withdrawal Symptoms

Meaning

Hormonal Withdrawal Symptoms are a constellation of adverse physical and psychological manifestations that occur when the administration of exogenous hormones is abruptly ceased or significantly reduced. These symptoms arise as the body, having suppressed its own endogenous hormone production in response to the external supply, struggles to rapidly re-establish normal function of the hypothalamic-pituitary-target gland axis. The specific symptoms, which can include fatigue, mood swings, hot flashes, or sleep disturbances, depend on the hormone involved and the duration of prior therapy. This clinical phenomenon underscores the importance of a gradual, supervised tapering schedule for hormone therapy cessation.