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Hormonal Trough Management

Meaning

Hormonal Trough Management is a clinical strategy focused on minimizing the lowest concentration points (the trough) of administered or endogenous hormones within the body’s circulation, particularly during hormone replacement therapy. An unmanaged trough can lead to a period of sub-therapeutic hormonal action, resulting in the recurrence of symptoms, such as fatigue or mood swings, before the next dose is administered. Effective management aims to maintain steady-state hormone levels above the minimum effective concentration throughout the dosing interval. This approach is essential for sustaining consistent clinical benefit and optimizing patient well-being.