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Hormonal Therapy Sequencing

Meaning

Hormonal Therapy Sequencing is the strategic, ordered administration of multiple distinct hormonal agents over time to manage chronic or progressive hormone-sensitive conditions, most notably advanced cancers. This clinical approach involves making deliberate choices about which agent to use first, which to use next, and the appropriate interval between treatments to maximize patient benefit and delay the emergence of therapeutic resistance. Effective sequencing requires continuous assessment of the patient’s disease status and the molecular profile of the tumor to anticipate and mitigate resistance mechanisms. The optimal sequence remains a critical area of ongoing clinical investigation in endocrinology and oncology.