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Hormonal Signaling Restoration

Meaning

The clinical process of re-establishing the optimal communication pathways between hormones and their target cell receptors, addressing issues of hormone deficiency, receptor downregulation, or impaired post-receptor signaling. Restoration aims to ensure that circulating hormones, whether endogenous or replaced, effectively elicit the appropriate biological response at the cellular level. This is a crucial distinction from simple hormone replacement, focusing on functional efficacy rather than just circulating concentration. It is fundamental to resolving symptoms associated with endocrine resistance or deficiency.