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Hormonal Signaling Fidelity

Meaning

Hormonal signaling fidelity describes the accuracy and reliability of the entire endocrine communication process, from the synthesis and release of a hormone to its binding at the target receptor and the subsequent intracellular response. High fidelity implies a clear, precise transmission of the hormonal message, leading to the correct and proportional physiological outcome. Conversely, reduced fidelity, often seen with aging or chronic stress, results in blunted or erroneous cellular responses, contributing to systemic dysfunction.