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Hormonal Signaling Disruption

Meaning

Hormonal Signaling Disruption describes any pathological interference with the normal synthesis, transport, receptor binding, or cellular response of endogenous hormones, leading to a cascade of systemic dysfunction. This disruption can be caused by intrinsic factors like genetic mutations or autoimmune attack, or extrinsic factors, such as endocrine-disrupting chemicals (EDCs) like phthalates and BPA. The clinical consequence is a state of hormonal imbalance, where the body’s essential regulatory communication is garbled, contributing to metabolic, reproductive, and neurological disorders. Identifying the source of this disruption is a critical step in restoring endocrine health.