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Hormonal Senescence Mitigation

Meaning

Hormonal Senescence Mitigation is the clinical strategy aimed at slowing or reversing the age-related decline in the production, signaling, and metabolic efficiency of key endocrine hormones. Senescence refers to the biological aging of cells and systems, and its hormonal manifestation includes the decline of anabolic hormones and the dysregulation of metabolic axes, contributing significantly to frailty and chronic disease. Effective mitigation involves personalized interventions to restore youthful hormone kinetics, optimize receptor sensitivity, and reduce the systemic inflammatory burden that accelerates endocrine aging. The goal is to preserve the robust hormonal milieu essential for vitality and longevity.