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Hormonal Resistance States

Meaning

Hormonal Resistance States describe a pathological condition where target tissues and cells exhibit a diminished or absent response to circulating hormones, despite the presence of normal or even elevated hormone concentrations in the bloodstream. This is a crucial functional impairment, distinct from simple hormone deficiency, that prevents the intended biological signal from being transduced effectively. Common examples include insulin resistance and peripheral androgen resistance, leading to systemic metabolic and functional decline. Addressing resistance is paramount for successful endocrine therapy.