Hormonal Regulation Attention refers to the specific influence exerted by the endocrine system on the neural circuits responsible for focusing and sustaining attention. It encompasses the direct and indirect modulation of neurotransmitter systems and brain energy metabolism by circulating hormones. Optimal hormonal regulation is necessary to maintain a stable, focused attentional state. This linkage highlights the systemic nature of cognitive function.
Origin
This term is a construct within neuroendocrinology, linking the systemic control mechanisms of hormones to the specific cognitive domain of attention. It recognizes that attention is not solely a neurological phenomenon but is profoundly shaped by the body’s chemical messengers. The term directs clinical focus toward the endocrine support of cognitive function, emphasizing the role of chemical messengers.
Mechanism
Glucocorticoids, like cortisol, exhibit a biphasic effect, with moderate levels enhancing attention and high chronic levels impairing prefrontal cortex function. Thyroid hormones directly affect the density of adrenergic receptors, influencing the norepinephrine system which is crucial for vigilance. Furthermore, sex hormones, such as estrogen, modulate dopamine and acetylcholine release in cortical areas, thereby influencing working memory and the ability to filter distractions.
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