Hormonal Influence on Sleep describes the bidirectional regulatory relationship between the endocrine system and the sleep-wake cycle, encompassing the timing and architecture of circadian rhythms. Key hormones like melatonin, cortisol, and growth hormone exhibit pulsatile release patterns tightly synchronized with sleep stages. Dysregulation in this axis frequently manifests as insomnia or non-restorative sleep.
Origin
This concept originates from chronobiology and neuroendocrinology, recognizing that hormones act as chemical timekeepers synchronizing bodily functions with the diurnal cycle. The influence is complex, involving feedback loops that dictate when sleep onset and maintenance occur.
Mechanism
Melatonin, secreted by the pineal gland, directly signals darkness and promotes sleep propensity, while the diurnal surge of cortisol signals wakefulness and metabolic readiness. Growth hormone secretion peaks during deep, slow-wave sleep, indicating that restorative processes are hormonally gated by sleep quality. Maintaining appropriate nocturnal cortisol suppression is essential for achieving sustained restorative sleep phases.
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