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Hormonal Half-Life

Meaning

Hormonal Half-Life is a key pharmacokinetic parameter defining the exact time required for the concentration of a specific hormone in the systemic circulation to decrease by precisely fifty percent of its peak or initial value. This metric is critically important in clinical endocrinology for accurately determining the appropriate dosing frequency, administration route, and formulation of hormone replacement therapies necessary to maintain stable, physiological blood levels. Hormones exhibit a wide spectrum of half-lives, ranging from mere minutes for certain peptide hormones to hours or even days for lipophilic steroid hormones.