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Hormonal Feedback Suppression

Meaning

This is a core endocrinological principle describing the inherent inhibitory effect of elevated circulating hormone levels on the release of their own stimulating hormones from the central hypothalamus and pituitary gland. It represents the body’s primary homeostatic mechanism, designed to prevent pathological overproduction and maintain hormone levels within a tightly controlled physiological range. Clinical interventions, such as the administration of exogenous hormones, often intentionally or unintentionally activate this natural suppression.