Skip to main content

Hormonal Feedback Loop Failure

Meaning

Hormonal Feedback Loop Failure describes a pathological state where the regulatory mechanism designed to maintain hormonal homeostasis malfunctions, resulting in the inappropriate over- or under-secretion of an endocrine product. This failure typically involves a breakdown in the communication between the stimulating gland (e.g., pituitary) and the target gland (e.g., thyroid or adrenal), often due to receptor insensitivity or structural damage. The clinical consequence is a state of chronic hormonal dysregulation that affects numerous systemic functions.