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Hormonal Feedback Interruption

Meaning

Hormonal Feedback Interruption is a pathological or therapeutically induced state where the normal reciprocal communication loop between an endocrine gland and its regulatory center, typically the hypothalamus and pituitary gland, is partially or completely blocked. This interruption prevents the circulating hormone concentration from accurately signaling back to the control center, leading to inappropriate, often exaggerated or suppressed, secretion of the upstream regulatory hormones. Clinical manifestations of interruption include secondary endocrine deficiencies or excesses, such as the suppression of endogenous testosterone production following exogenous hormone administration.