The gradual, often subclinical, deviation of circulating hormone levels, such as androgens or thyroid hormones, away from the individual’s established physiological set-point over time.
Origin
This nomenclature describes the slow, cumulative effect of aging, environmental stressors, or lifestyle factors on the endocrine feedback loops, leading to functional decline.
Mechanism
Drift occurs due to subtle impairments in hypothalamic-pituitary signaling, altered steroidogenesis, or increased peripheral hormone clearance rates, manifesting as subtle but persistent shifts in homeostasis.
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