A conceptual framework that views the body’s steroid hormones, particularly those derived from cholesterol, as a finite and convertible resource pool that must be judiciously regulated for systemic health. This management involves optimizing the synthesis, conversion, and clearance pathways of key hormones like cortisol, DHEA, and the sex steroids. Effective management ensures resources are appropriately allocated to stress response, metabolism, and reproductive function.
Origin
This term is a clinical metaphor, likening the body’s hormone production and utilization to the economic principle of managing a valuable, circulating ‘currency’. It is central to the practice of functional and integrative endocrinology, which emphasizes the interconnectedness of steroidogenesis and the concept of a ‘pregnenolone steal’ or ‘cortisol steal’ phenomenon.
Mechanism
The core mechanism is rooted in the steroidogenesis pathway within the adrenal glands and gonads, where cholesterol is sequentially converted into various active hormones. The Hypothalamic-Pituitary-Adrenal (HPA) axis often dictates the resource allocation, prioritizing cortisol production under chronic stress. Optimal management involves nutritional and lifestyle interventions to support precursor availability and enzyme activity, ensuring balanced downstream production of all vital steroid hormones.
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