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Hormonal Cognitive Impact

Meaning

Hormonal Cognitive Impact describes the profound and multifaceted influence that endocrine signaling molecules exert on brain structure, function, and overall cognitive performance throughout the lifespan. Fluctuations or deficiencies in key hormones, such as thyroid hormones, estrogen, testosterone, and cortisol, directly affect neuronal excitability, synaptic plasticity, and mood regulation. Clinical practice focuses on assessing and optimizing these hormonal levels to mitigate cognitive symptoms like “brain fog” or memory impairment. This impact underscores the brain’s status as a major target organ for the endocrine system.