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Hormonal Cascade Sequence

Meaning

The Hormonal Cascade Sequence describes the ordered, sequential activation of multiple endocrine glands and their respective hormones, often initiated by a signal from the central nervous system. This sequence represents a fundamental principle of the endocrine system, ensuring precise, regulated physiological responses to various internal or external stimuli, such as stress or circadian cues. A classic example is the Hypothalamic-Pituitary-Adrenal (HPA) axis, where one hormone triggers the release of the next in a controlled, feedback-regulated manner. Maintaining the integrity of this cascade is vital for systemic homeostasis and metabolic health.