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Hormonal Cascade Integrity

Meaning

Hormonal Cascade Integrity refers to the flawless, sequential operation of the endocrine signaling pathways, starting from the hypothalamic-pituitary axis down to the peripheral target glands and their corresponding receptor responses. This integrity is the measure of how accurately and efficiently the body transmits and executes hormonal commands. Any disruption, or “break,” in this cascade—such as pituitary dysfunction or peripheral receptor resistance—compromises systemic health and homeostatic control. Maintaining this integrity is essential for metabolic and reproductive function.