Skip to main content

Hormonal Bioavailability Enhancement

Meaning

Hormonal Bioavailability Enhancement is a therapeutic or nutritional strategy focused on increasing the fraction of an administered or endogenously produced hormone that reaches the systemic circulation and is available to exert its biological effect at target tissues. This enhancement can be achieved by improving absorption across the intestinal or dermal barrier, reducing first-pass metabolism in the liver, or modulating carrier proteins like Sex Hormone-Binding Globulin (SHBG). The clinical goal is to maximize the efficacy of a given hormonal dose or optimize the action of native hormones. Achieving this is paramount for effective hormonal replacement and balancing therapies.