Skip to main content

Hormonal Axis Coupling

Meaning

Hormonal Axis Coupling refers to the complex, integrated communication and regulatory feedback loops that exist between two or more major neuroendocrine axes, such as the Hypothalamic-Pituitary-Adrenal (HPA) and the Hypothalamic-Pituitary-Gonadal (HPG) axes. This coupling signifies that the activity of one axis is profoundly influenced by the output and regulatory signals of the other, ensuring systemic hormonal harmony. Optimal coupling is essential for maintaining homeostasis, reproductive function, and stress resilience, while decoupling or dysregulation can lead to a cascade of endocrine pathologies.