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HRTioSeptember 29, 2025
Hormonal Amplitude Decline
Meaning
Hormonal Amplitude Decline describes the age-related reduction in the magnitude of the pulsatile release of various endocrine signals, even if the average daily concentration of the hormone remains within the statistical normal range. This decline is characterized by a significant blunting of the peak secretory pulses, leading to a loss of the robust, high-amplitude signaling necessary for optimal cellular response. It is a key physiological hallmark of endocrine aging and reduced biological vitality.
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