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HOMA-IR Improvement

Meaning

HOMA-IR Improvement refers to a clinically significant reduction in the calculated Homeostasis Model Assessment of Insulin Resistance index, signifying an enhancement in the body’s sensitivity to insulin. This mathematical model provides a surrogate measure of beta-cell function and insulin resistance by utilizing fasting glucose and fasting insulin levels. Achieving HOMA-IR improvement is a primary therapeutic goal in managing pre-diabetes, metabolic syndrome, and hormonal conditions like Polycystic Ovary Syndrome (PCOS), which are often characterized by insulin dysregulation.