What is the Origin of HOMA-IR Correction?

The term originates from clinical endocrinology, utilizing the HOMA-IR calculation (fasting glucose and insulin) as a proxy for whole-body insulin resistance status. Correction implies reversing this measurable metabolic impairment.

What is the Mechanism of HOMA-IR Correction?

Correction typically involves interventions that improve peripheral tissue sensitivity to insulin, such as dietary composition adjustments or optimizing adipokine profiles through weight management. Enhancing the cellular response to insulin signaling indirectly supports brain metabolic function and reduces systemic inflammatory load. Restoration of euglycemia mitigates secondary damage pathways associated with hyperinsulinemia.

HOMA-IR Correction

Meaning

The clinical process of reducing an elevated Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score through lifestyle modification and targeted endocrinological support. A high HOMA-IR signifies systemic inefficiency in glucose disposal, which negatively impacts vascular and neurological health. Correction restores appropriate insulin signaling sensitivity.