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HLA-DQA1 05

Meaning

HLA-DQA1 05 refers to a specific allele, or genetic variant, of the Human Leukocyte Antigen DQA1 gene, which encodes a subunit of the HLA-DQ protein complex found on the surface of immune cells. This complex is crucial for presenting antigens to T-cells, effectively distinguishing self from non-self. The presence of the HLA-DQA105 allele is clinically significant because it is strongly associated with a genetic predisposition to several autoimmune endocrine disorders.