What is the Origin of Histone Deacetylase (HDAC) Inhibitors?

The name describes the molecular target: Histone Deacetylases (enzymes that remove acetyl groups) and the action of the drug class (Inhibitors). These compounds emerged from cancer research but have implications for understanding epigenetic regulation of hormone receptor expression.

What is the Mechanism of Histone Deacetylase (HDAC) Inhibitors?

By inhibiting HDACs, these compounds increase histone acetylation, leading to a more open chromatin structure (euchromatin). This opening allows for increased access by transcription factors to specific gene promoters, thereby increasing the expression of certain genes, often tumor suppressors or genes involved in differentiation. In endocrine signaling, this can influence the expression of receptors or enzymes crucial for hormone response pathways.

Histone Deacetylase (HDAC) Inhibitors ∞ Area

Histone Deacetylase (HDAC) Inhibitors

Meaning

A class of pharmacological agents that function by blocking the activity of Histone Deacetylase enzymes, thereby promoting the acetylation of histone proteins within the cell nucleus. This manipulation of chromatin structure is a powerful epigenetic mechanism used in various therapeutic areas, including some endocrine-related cancers. They fundamentally alter gene transcription patterns.