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Histamine Response

Meaning

The Histamine Response is a critical physiological reaction initiated by the release of the biogenic amine histamine from mast cells and basophils, primarily serving as a key mediator of immediate hypersensitivity and local immune defense. This response is characterized by local vasodilation, increased capillary permeability, and the contraction of smooth muscles, manifesting clinically as inflammation, itching, and allergy symptoms. Within the hormonal context, histamine and its receptors are intricately linked to estrogen signaling, often influencing the severity of allergic and inflammatory conditions, particularly during phases of high estradiol concentration.