Question 1

What is the Meaning of hiPSC-Cardiomyocytes?

Accepted Answer

hiPSC-Cardiomyocytes are human induced pluripotent stem cell-derived heart muscle cells, representing a highly valuable in vitro model for studying cardiac biology and screening drug safety. These cells are generated by genetically reprogramming adult somatic cells back into a pluripotent state, which are then differentiated into spontaneously beating heart cells. They offer a human-specific platform for preclinical research.

Question 2

What is the Origin of hiPSC-Cardiomyocytes?

Accepted Answer

This technology originated from the Nobel Prize-winning work of Shinya Yamanaka in 2006, who demonstrated that mature cells could be reprogrammed into an embryonic-like state using specific transcription factors. The subsequent application to generate patient-specific cardiomyocytes revolutionized the field of personalized medicine and drug development.

Question 3

What is the Mechanism of hiPSC-Cardiomyocytes?

Accepted Answer

The functional mechanism is their ability to recapitulate the contractile and electrophysiological properties of human heart cells in a dish, albeit with an immature phenotype compared to adult tissue. They are used extensively to test the cardiotoxic potential of new drug candidates, such as anthracyclines, by quantifying changes in cellular contractility, viability, and the propensity for arrhythmias.

hiPSC-Cardiomyocytes

Meaning

Origin

Mechanism

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