Hippocampal Volume Neurogenesis refers to the clinical objective of stimulating the formation of new neurons (neurogenesis) specifically within the hippocampus, a brain region critical for memory consolidation, learning, and emotional regulation. Reduced hippocampal volume is a common finding in chronic stress, depression, and neurodegenerative conditions, often linked to sustained cortisol exposure. Promoting neurogenesis is a key strategy in cognitive longevity and mental health protocols, aiming to physically restore brain structure and functional plasticity. The focus is on enhancing the brain’s intrinsic repair and growth mechanisms to improve cognitive reserve.
Origin
The traditional neurological dogma that the adult brain could not generate new neurons was overturned by research in the late 20th century, which confirmed adult neurogenesis in the hippocampus and subventricular zone. The clinical term reflects the therapeutic goal of leveraging this innate plasticity. This concept is foundational to modern neuropsychiatry and longevity medicine, emphasizing that brain structure is not static but dynamically responsive to environment and intervention.
Mechanism
Neurogenesis is primarily regulated by the Brain-Derived Neurotrophic Factor (BDNF), a protein that supports the survival and differentiation of new neurons. Interventions, including aerobic exercise, caloric restriction, and specific nutritional compounds, act by upregulating BDNF gene expression. Furthermore, the reduction of chronic stress and the normalization of cortisol levels mitigate the excitotoxic and atrophic effects of glucocorticoids on hippocampal cells. The combined mechanism promotes progenitor cell proliferation and their successful integration into existing neural circuits, physically increasing hippocampal volume and function.
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