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Hippocampal GABA

Meaning

Hippocampal GABA refers to the presence and critical function of Gamma-Aminobutyric Acid within the hippocampus, a temporal lobe structure vital for memory consolidation, spatial navigation, and emotional regulation. GABA is the primary inhibitory neurotransmitter in the central nervous system, and its controlled action in the hippocampus is essential for modulating neuronal network excitability and facilitating synaptic plasticity. Clinical research implicates dysregulated hippocampal GABAergic signaling in the pathology of anxiety, stress-related disorders, and certain forms of cognitive impairment.