What is the Origin of High Sensitivity CRP?

This measurement technique evolved from traditional immunology, where CRP was identified as an acute phase reactant produced by the liver. The 'high sensitivity' modification allows for the detection of subtle, chronic inflammatory states often preceding overt disease. Its utility in wellness science is recognizing subclinical inflammatory burdens.

What is the Mechanism of High Sensitivity CRP?

CRP is an acute-phase reactant synthesized in response to interleukin-6 (IL-6) signaling, which is often triggered by metabolic stress or tissue damage. Chronically elevated levels reflect ongoing, low-level activation of the innate immune system, which can interfere with insulin signaling and receptor function for other key hormones. Reducing this systemic inflammatory noise is a primary goal in restoring hormonal milieu stabilization.

High Sensitivity CRP

Meaning

High-Sensitivity C-Reactive Protein (hs-CRP) is a highly sensitive quantitative measure of systemic, low-grade inflammation, which is distinct from the standard CRP test that detects acute inflammatory spikes. Persistently elevated hs-CRP levels are a critical functional biomarker indicating chronic tissue irritation that negatively impacts cardiovascular and endocrine health. Understanding this marker is foundational to managing systemic vitality.