What is the Origin of High-Sensitivity C-Reactive Protein?

This term denotes an evolution of the standard CRP test, employing a more sensitive methodology to detect subtle, chronic inflammatory states rather than just acute infection. It originates from immunology and clinical chemistry. Its significance lies in its predictive value for chronic disease development.

What is the Mechanism of High-Sensitivity C-Reactive Protein?

Elevated hs-CRP levels reflect the ongoing release of pro-inflammatory cytokines, often originating from dysfunctional adipose tissue, which directly interferes with insulin receptor signaling cascades. This chronic inflammatory state can impair the function of endocrine glands and contribute to endothelial dysfunction. Persistent elevation signals a need to address underlying metabolic perturbations.

High-Sensitivity C-Reactive Protein

Meaning

High-Sensitivity C-Reactive Protein (hs-CRP) is a quantitative assay measuring low concentrations of C-Reactive Protein, a key acute-phase reactant indicating systemic, low-grade inflammation. Elevated hs-CRP levels are recognized as an independent risk factor for cardiovascular events and are closely correlated with insulin resistance and metabolic syndrome components. We use this biomarker to gauge the level of chronic physiological stress impacting tissues.

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