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High-Resolution Mass Spectrometry

Meaning

High-Resolution Mass Spectrometry (HRMS) is a sophisticated analytical technique used in clinical chemistry and endocrinology to precisely identify and quantify minute concentrations of molecules, such as hormones and their metabolites, within biological samples. This method achieves unparalleled specificity and sensitivity by measuring the mass-to-charge ratio of ionized compounds with extreme accuracy, allowing for the differentiation of compounds with very similar molecular weights. Clinically, HRMS is considered the gold standard for accurately measuring low-abundance steroid hormones, circumventing the cross-reactivity issues often encountered with less precise immunoassay techniques. Its application ensures highly reliable data for personalized hormonal health management and research.