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High-Normal Free Hormones

Meaning

High-Normal Free Hormones refers to the clinical objective of maintaining the circulating, unbound fraction of key steroid and thyroid hormones at the upper end of the established laboratory reference range, but still strictly within the statistically normal limits. The ‘free’ fraction is the biologically active component capable of binding to intracellular receptors and exerting its effect, making its concentration the most relevant metric for tissue function. This target range is often pursued to support optimal cellular signaling, vitality, and anabolism, aiming for the levels typically associated with peak youthful function rather than the average for a broader, often aging, population.