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High-Leverage Output

Meaning

High-Leverage Output is a clinical outcome where a minimal, precise intervention in a central regulatory system yields a disproportionately large and beneficial effect across multiple downstream physiological processes. In the context of hormonal health, this refers to targeting a key upstream control point, such as a master gland or a fundamental metabolic switch. Achieving high-leverage output is the goal of precision medicine, maximizing therapeutic impact while minimizing systemic disruption.